To avoid crowd evacuation simulations depending on 2D environments and real data, we propose a framework for crowd evacuation modeling and simulation by applying deep reinforcement learning (DRL) and 3D physical environments (3DPEs).In 3DPEs, we construct simulation scenarios from the aspects of geometry, semantics and physics, which include the en
Current cancer therapeutics often insufficiently eradicate malignant cells due to the surrounding dense tumor stroma.This multi-componential tissue consists of mainly cancer-associated fibroblasts, the (compact) extracellular matrix, tumor vasculature, and tumor-associated macrophages, which all exert crucial roles in maintaining a pro-tumoral nich
Matrix-deprivation stress leads to cell-death by anoikis, whereas overcoming anoikis is critical for cancer metastasis.Work from our ilootpaperie lab and others has identified a crucial role for the cellular energy sensor AMPK in anoikis-resistance, highlighting a key role for metabolic reprogramming in stress survival.Protein synthesis is a major
The camber and cornering properties of the tire directly affect the handling stability of vehicles, especially in emergencies such as high-speed cornering and obstacle avoidance.The structural and load-bearing mode of non-pneumatic mechanical elastic (ME) wheel determine that the mechanical properties of ME wheel will change when different combinat